@unpublished {orozco2024IPaspire,
	title = {ASPIRE: Iterative Amortized Posterior Inference for Bayesian Inverse Problems},
	year = {2024},
	month = {5},
	abstract = {Due to their uncertainty quantification, Bayesian solutions to inverse problems are the framework of choice in applications that are risk averse. These benefits come at the cost of computations that are in general, intractable. New advances in machine learning and variational inference (VI) have lowered the computational barrier by learning from examples. Two VI paradigms have emerged that represent different tradeoffs: amortized and non-amortized. Amortized VI can produce fast results but due to generalizing to many observed datasets it produces suboptimal inference results. Non-amortized VI is slower at inference but finds better posterior approximations since it is specialized towards a single observed dataset. Current amortized VI techniques run into a sub-optimality wall that can not be improved without more expressive neural networks or extra training data. We present a solution that enables iterative improvement of amortized posteriors that uses the same networks architectures and training data. The benefits of our method requires extra computations but these remain frugal since they are based on physics-hybrid methods and summary statistics. Importantly, these computations remain mostly offline thus our method maintains cheap and reusable online evaluation while bridging the approximation gap these two paradigms. We denote our proposed method ASPIRE - Amortized posteriors with Summaries that are Physics-based and Iteratively REfined. We first validate our method on a stylized problem with a known posterior then demonstrate its practical use on a high-dimensional and nonlinear transcranial medical imaging problem with ultrasound. Compared with the baseline and previous methods from the literature our method stands out as an computationally efficient and high-fidelity method for posterior inference.},
	keywords = {Amortization Gap, Amortized Variational Inference, Bayesian inference, medical imaging, Normalizing flows, simulation-based inference},
	doi = {10.48550/arXiv.2405.05398},
	author = {Rafael Orozco and Ali Siahkoohi and Mathias Louboutin and Felix J. Herrmann}
}
@conference {orozco2022SPIEadjoint,
	title = {Adjoint operators enable fast and amortized machine learning based Bayesian uncertainty quantification},
	booktitle = {SPIE Medical Imaging Conference},
	year = {2023},
	note = {(SPIE, San Diego)},
	month = {02},
	abstract = {Machine learning algorithms such as Normalizing Flows, VAEs, and GANs are powerful tools in Bayesian uncertainty quantification (UQ) of inverse problems. Unfortunately, when using these algorithms medical imaging practitioners are faced with the challenging task of manually defining neural networks that can handle complicated inputs such as acoustic data. This task needs to be replicated for different receiver types or configurations since these change the dimensionality of the input. We propose to first transform the data using the adjoint operator {\textemdash}ex: time reversal in photoacoustic imaging (PAI) or back-projection in computer tomography (CT) imaging {\textemdash} then continue posterior inference using the adjoint data as an input now that it has been standardized to the size of the unknown model. This adjoint preprocessing technique has been used in previous works but with minimal discussion on if it is biased. In this work, we prove that conditioning on adjoint data is unbiased for a certain class of inverse problems. We then demonstrate with two medical imaging examples (PAI and CT) that adjoints enable two things: Firstly, adjoints partially undo the physics of the forward operator resulting in faster convergence of an ML based Bayesian UQ technique. Secondly, the algorithm is now robust to changes in the observed data caused by differing transducer subsampling in PAI and number of angles in CT. Our adjoint-based Bayesian inference method results in point estimates that are faster to compute than traditional baselines and show higher SSIM metrics, while also providing validated UQ.},
	keywords = {Amortized Inference, Bayesian inference, deep learning, Inverse problems, machine learning, medical imaging, Normalizing flows, SPIE, Uncertainty quantification},
	url = {https://slim.gatech.edu/Publications/Public/Conferences/SPIE/2023/orozco2022SPIEadjoint/SPIE_2022_adjoint.html},
	author = {Rafael Orozco and Ali Siahkoohi and Gabrio Rizzuti and Tristan van Leeuwen and Felix J. Herrmann}
}
@conference {orozco2023MIDLanf,
	title = {Amortized normalizing flows for transcranial ultrasound with uncertainty quantification},
	booktitle = {Medical Imaging with Deep Learning},
	year = {2023},
	note = {(MIDL, Nashville)},
	month = {07},
	abstract = {We present a novel approach to transcranial ultrasound computed tomography that utilizes normalizing flows to improve the speed of imaging and provide Bayesian uncertainty quantification. Our method combines physics-informed methods and data-driven methods to accelerate the reconstruction of the final image. We make use of a physics-informed summary statistic to incorporate the known ultrasound physics with the goal of compressing large incoming observations. This compression enables efficient training of the normalizing flow and standardizes the size of the data regardless of imaging configurations. The combinations of these methods results in fast uncertainty-aware image reconstruction that generalizes to a variety of transducer configurations. We evaluate our approach with in silico experiments and demonstrate that it can significantly improve the imaging speed while quantifying uncertainty. We validate the quality of our image reconstructions by comparing against the traditional physics-only method and also verify that our provided uncertainty is calibrated with the error.},
	keywords = {Bayesian Estimation, invertible networks, medical imaging, MIDL, Physics and Machine Learning Hybrid, Uncertainty quantification},
	url = {https://slim.gatech.edu/Publications/Public/Conferences/MIDL/2023/orozco2023MIDLanf/paper.pdf},
	author = {Rafael Orozco and Mathias Louboutin and Ali Siahkoohi and Gabrio Rizzuti and Tristan van Leeuwen and Felix J. Herrmann}
}
@presentation {orozco2022ML4SEISMICaos,
	title = {Adjoint operators as summary functions in amortized Bayesian inference frameworks},
	year = {2022},
	month = {11},
	abstract = {An important concern in seismic inverse problems is the large and varying size of observed data. The large size can cause computational cost concerns and its varying size (such as when changing receiver geometries) implies the need to rerun inference algorithms from scratch for each new observation. Motivated by these two problems, we take inspiration from the statistics literature which commonly relies on summary statistic of observed data. Summary statistic compress the observed data leaving only information needed for inference. In this work, we argue that the adjoint operator provides a natural candidate for a summary function in the context of physics-based inverse problems. We first mathematically show that for certain general assumptions transforming data under the adjoint operator defines a new conditional distribution which preserves the expectations of the original posterior. We validate our hypothesis by evaluating our framework in a learned amortized inference algorithm. Our seismic and medical synthetic experiments show computational gains and increased quality of point estimates using our framework. We discuss statistical metrics that show our learned posterior is well calibrated therefore justifying its use in uncertainty quantification.},
	keywords = {Amortized Inference, Bayesian inference, deep learning, Inverse problems, machine learning, medical imaging, ML4SEISMIC, Normalizing flows, SLIM, Uncertainty quantification},
	url = {https://slim.gatech.edu/Publications/Public/Conferences/ML4SEISMIC/2022/orozco2022ML4SEISMICaos/index.html},
	author = {Rafael Orozco and Mathias Louboutin and Ali Siahkoohi and Gabrio Rizzuti and Felix J. Herrmann}
}
@techreport {orozco2022MIDLmei,
	title = {Memory Efficient Invertible Neural Networks for 3D Photoacoustic Imaging},
	number = {TR-CSE-2022-2},
	year = {2022},
	month = {04},
	abstract = {Photoacoustic imaging (PAI) can image high-resolution structures of clinical interest such as vascularity in cancerous tumor monitoring. When imaging human subjects, geometric restrictions force limited-view data retrieval causing imaging artifacts. Iterative physical model based approaches reduce artifacts but require prohibitively time consuming PDE solves. Machine learning (ML) has accelerated PAI by combining physical models and learned networks. However, the depth and overall power of ML methods is limited by memory intensive training. We propose using invertible neural networks (INNs) to alleviate memory pressure. We demonstrate INNs can image 3D photoacoustic volumes in the setting of limited-view, noisy, and subsampled data. The frugal constant memory usage of INNs enables us to train an arbitrary depth of learned layers on a consumer GPU with 16GB RAM.},
	keywords = {invertible networks, medical imaging, photoacoustic imaging, Physics and Machine Learning Hybrid},
	url = {https://slim.gatech.edu/Publications/Public/TechReport/2022/orozco2022MIDLmei/midl_2022.html},
	author = {Rafael Orozco and Mathias Louboutin and Felix J. Herrmann}
}
@conference {herrmann2021Delftlwi,
	title = {Learned wave-based imaging - variational inference at scale},
	booktitle = {Delft},
	year = {2021},
	note = {(Delft, virtual)},
	month = {06},
	abstract = {High dimensionality, complex physics, and lack of access to the ground truth rank medical ultrasound and seismic imaging amongst the most challenging problems in the computational imaging sciences. If these challenges were not bad enough, modern applications of computational imaging increasingly call for the assessment of uncertainty on the image itself and on subsequent tasks. During this talk, I will show how recent developments in Normalizing Flows, a new type of invertible neural networks, can be used to cast wave-based imaging into a scalable Bayesian framework. Contrary to conventional methods, where sample images are drawn from the posterior distribution during inversion, our approach trains Normalizing Flows capable of generating samples from the posterior. Aside from greatly reducing the computational cost, this approach gives us access to the image itself (via Maximum a posteriori or mean estimation) and its multidimensional statistical distribution including its pointwise variance.},
	keywords = {medical imaging, Normalizing flows, seismic imaging, Uncertainty quantification},
	url = {https://slim.gatech.edu/Publications/Public/Conferences/Delft/2021/herrmann2021Delftlwi/herrmann2021Delftlwi.pdf},
	url2 = {https://slim.gatech.edu/Publications/Public/Conferences/Delft/2021/herrmann2021Delftlwi/herrmann2021Delftlwi.mp4},
	author = {Felix J. Herrmann and Ali Siahkoohi and Rafael Orozco and Gabrio Rizzuti and Philipp A. Witte and Mathias Louboutin}
}
@conference {yin2020SEGesi,
	title = {Extended source imaging {\textendash}- a unifying framework for seismic and medical imaging},
	booktitle = {SEG Technical Program Expanded Abstracts},
	year = {2020},
	note = {(SEG, virtual)},
	month = {09},
	pages = {3502-3506},
	abstract = {We present three imaging modalities that live on the crossroads of seismic and medical imaging. Through the lens of extended source imaging, we can draw deep connections among the fields of wave-equation based seismic and medical imaging, despite first appearances. From the seismic perspective, we underline the importance to work with the correct physics and spatially varying velocity fields. Medical imaging, on the other hand, opens the possibility for new imaging modalities where outside stimuli, such as laser or radar pulses, can not only be used to identify endogenous optical or thermal contrasts but that these sources can also be used to insonify the medium so that images of the whole specimen can in principle be created.},
	keywords = {medical imaging, SEG, seismic imaging, variable projection},
	doi = {10.1190/segam2020-3426999.1},
	url = {https://slim.gatech.edu/Publications/Public/Conferences/SEG/2020/yin2020SEGesi/yin2020SEGesi.html},
	presentation = {https://slim.gatech.edu/Publications/Public/Conferences/SEG/2020/yin2020SEGesi/yin2020SEGesi_pres.pdf},
	url2 = {https://slim.gatech.edu/Publications/Public/Conferences/SEG/2020/yin2020SEGesi/yin2020SEGesi_pres.mp4},
	software = {https://github.com/slimgroup/Software.SEG2020},
	author = {Ziyi Yin and Rafael Orozco and Philipp A. Witte and Mathias Louboutin and Gabrio Rizzuti and Felix J. Herrmann}
}
